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KMID : 0377619640060060651
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Korean Jungang Medical Journal
1964 Volume.6 No. 6 p.651 ~ p.655
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Immunogical Studies on Gamma Ray(Co^(60)) Irradiated S.typhi(42-A-58)
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千世榮/Chun, S.Y.
崔大卿/柳駿/Choi, T.K./Lew,J.
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Abstract
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In Korea, enteric infectious diseases are found throughout the year, in endemic,, as well as epidemic fashions. For the preventions such diseases, notably typhoid and paratyphoid fevers, bacterial suspension killed by heating. process have used conventionally. However, these heat killed vaccine cannot be expected to possess the sufficieient antigenicity as in case clinical or subclinical infection.
Previously, the authors studied gamma ray irradiated Mycobacterium tuberculosis. The experimental results have performed an immunological study of gamma ray in-a-.
Mycobacterium tuberculosis, and found that they are superior to the conventional BCG vaccines in the immunization process.
These gamma irradiated bacteria are known to be incapable of cell -divisions and multiplications, but capable of performing minimum oxygen uptake, and therefore not virulent to cause the diseases.
In view. of the above fact, the authors have done an experimental study in which 42-A-58 strain of Salmonella typhi was selected and gamma ray irradiation of the minimal dosage sufficient to stop division and multiplication was given. These irradiated strains were injected to animals and compared to the chemical treated typhoid bacilli processed similarly. The irradiated group showed elevation of 0 and H antibody titers comparable to the chemically treated group.
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